Research in Ocular Inflammatory Diseases

The following information is provided as a service to the uveitis community...

Investigational Medicine, LX211 (voclosporin), for Noninfectious Uveitis

Noninfectious uveitis is an autoimmune disease that causes re-occurring inflammation of the eye. Symptoms may include vision loss, redness of the eye, blurred vision, and ocular pain. Uveitis is one of the leading causes of blindness worldwide.

The LX211-11 research study is evaluating the use of LX211, an investigational immunosuppressive agent, for its ability to control active inflammation associated with uveitis. LX211 is taken in soft gelatin capsule form and has been studied in over 550 patients worldwide.

For more information about the LX211-11 research study, please see www.clinicaltrials.gov, ID# NCT01243983

Posted 2011-06-09

Abbott VISUAL Clinical Trials
Trial website www.uveitisclinicaltrials.com

Efficacy and Safety of Adalimumab in Subjects With Active Uveitis (VISUAL I) Link #1: http://clinicaltrials.gov/ct2/show/NCT01138657?term=Abbott+uveitis&rank=2

Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis (Visual II) Link #2: http://clinicaltrials.gov/ct2/show/NCT01124838?term=Abbott+uveitis&rank=1

Eyegate Pharmaceuticals, Inc. is currently running a Uveitis Clinical
Trial at various locations throughout the country for people with
Non-Infectious Acute Anterior Segment Uveitis. This study will involve the investigation of a unique drug delivery system that may facilitate the delivery of ophthalmic medications to the eye so as to maximize treatment efficacy. The research is taking place at the following locations. Please contact the appropriate coordinator below to determine if you are good match for this study.

Cambridge, MA: Jennifer Pinto 617.494.1430

Boston, MA: Jackie Pereira 617.573.1027

NYC: Katy Tai 212.979.4251

Chicago, IL: Misel Ramirez 312.996.4747

Cleveland, OH: Laura Holody 216.444.2020

Norfolk, VA: Nancy Crawford 757.622.2200

Dublin, OH: Jennifer Brown 614.339.8500

Philadelphia, PA: Joan Dupont 215.662.8038

Dallas, TX: Jean Arnwine 214.692.6885 ext. 1

Portland, OR: Casey Eye Institute

HELP UVEITIS RESEARCH EFFORTS

We are looking for participants for a genetic study of uveitis.

We are conducting a research study to search for genes or genetic factors that contribute to the development of an inflammatory eye disease called uveitis (or iritis).  Many patients with uveitis have other inflammatory diseases.  Our ultimate goal is to be able to treat or even to prevent uveitis by better understanding the genetics of uveitis.

You may be eligible to participate if you:

• Are healthy, with no inflammatory disease.
• Have an inflammatory disease, but not uveitis.
• Have uveitis, with or without other inflammatory disease.
• Have a family member with uveitis.

Your personal involvement in this research will take approximately 1 to 4 hours.  You will be asked to provide personal medical details or records that relate to your disease and to donate a blood sample which will be used for genetic research. 

You will not personally benefit from participating in this study.  However, by serving as a research subject, you may contribute new information that may benefit patients in the future.

If you would like to participate, please contact the study coordinator:

503-494-3689 (local) or 866-338-3789 (toll-free)

email: uveitisg@ohsu.edu

Thank you!

Tammy M. Martin, Ph.D.

James T. Rosenbaum, M.D.

Justine R. Smith, M.D., Ph.D.

Eric B. Suhler, M.D.

Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239

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